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Syövän genetiikka/Cancer genetics

Examination 9.2.2015

Lectures

  1. RB. Gene, function and it's link to hereditary cancer syndrome.
  2. Gene alterations by chromosomal translocations in leukemias and lymphomas. Use the activation of MYC- and ABL-proto-oncogenes as examples.

Literature

The hallmarks of cancer

Extra

The benefits and difficulties of gene testing (Your own opinion).

Examination 20.03.2013

Lectures

  1. Explain shortly
    1. Gatekeeper
    2. Caretaker
    3. Amplicon
    4. LOI
    5. Epigenome
  2. Gene alterations by chromosomal translocations in leukemias and lymphomas. Use the Activation of Myc- and ABL-proto-oncogenes as examples

Literature

  1. How epigenetics and genetics can co-operate during tumorigenesis

13.2.2013

Lectures

  1. Explain shortly:
    1. Gatekeeper
    2. Caretaker
    3. Epigenome
    4. Amplicon
    5. NIN, MIN, CIN
  2. Genomic imprinting and LOI

Literature:

Single-gene disorders involving an inherited susceptibility to colorectal cancer.

Extra (1 point)

The benefits and difficulties of gene testing (Your own opinion).

7.4.2009

Lectures

  1. Explain shortly:
  • Aneuploidy
  • Gatekeeper
  • Caretaker
  • “Two hit” -mechanism
  • Apoptosis
  • NIN, MIN, CIN
  1. RB. Gene, function and it's link to hereditary cancer syndrome.
  2. Genomic imprinting and LOI

Literature:

Breast cancer associated cancer predisposition syndromes. The lecture part gives 2 ects. The lecture part together with literature gives 3 etcs (both parts need to be passed).

3.3.2009

Lectures

1. Gene alterations by chromosomal translocations in leukemias and lymphomas. Use the activation of MYC- and ABL-proto-oncogenes as examples.

2. Cancer genes.

3. Genomic imprinting and LOI

Literature

Single-gene disorders involving an inherited susceptibility to colorectal cancer.

The lecture part gives 2 ects. The lecture part together with literature gives 3 etcs (both parts need to be passed).

9.2.2009

Lectures

1. Exaplain shortly

  • Tumor
  • Cancer
  • Oncogene
  • Tumor suppressor gene
  • Mismatch repair gene
  • Gatekeeper
  • Caretaker
  • LOI
  • Amplicon
  • NIN, MIN, CIN

2. Gene alterations by chromosomal translocations in leukemias and lymphomas. Use the activation of MYC- and ABL-proto-oncogenes as examples.

3. The regulations of cyclin-dependent kinases in cell cycle control

Extra Question

Benefits and disadvantages of gene testing in familial cancer (your own opinion, short answer!)

Literature

  1. RB and cancer. RB ja syöpä.

The lecture part gives 2 ects. The lecture part together with literature gives 3 etcs (both parts need to be passed).

1.4.2008

Lectures

  1. Gene alterations by chromosomal translocations in leukemias and lymphomas. Use the activation of MYC- and ABL-proto-oncogenes as examples. Kromosomaalisten translokaatioiden aiheuttamat geenimuutokset leukemioissa ja lymfoomissa. Esimerkkeinä MYC- ja ABL- proto-onkogeenien aktivoituminen.
  2. The regulations of cyclin-dependent kinases in cell cycle control. Solusyklin säätelyssä toimivien CDK-proteiinikinaasien erilaiset säätelyt.
  3. MMR and cancer. MMR ja syöpä.

Literature

  1. RB and cancer. RB ja syöpä.

The lecture part gives 2 ects. The lecture part together with literature gives 3 etcs (both parts need to be passed).

11.2.2008

1. Explain shortly

  • Tumor
  • Cancer
  • Oncogene
  • Tumor suppressor gene
  • Mismatch repair gene
  • Gatekeeper
  • Caretaker
  • LOI
  • Amplicon
  • NIN, MIN, CIN

2. Gene alterations by chromosomal translocation in leukemias and lymphomas. Use the activation of MYC- and ABL-proto-oncogenes as examples.

3. The regulations of cyclin-dependent kinases in cell cycle control

4. Benefits and disadvantages of gene testing in familial cancer (your own opinion)

Literature: RB and cancer

14.2.2007

1. Määrittele lyhyesti

  • Tuumori
  • Syöpä
  • Genomin “imprinting”
  • Onkogeeni
  • Tuumorisupressorigeeni

2. Määrittele lyhyesti

  • “Two hit”-mekanismi
  • LOI
  • Amplicon
  • NIN, MIN, CIN
  • Apoptoosi

3. Kromosomaalisten translokaatioiden aiheuttamat geenimuutokset leukemioissa ja lymfoomissa. Esimerkkeinä MYC- ja ABL- proto-onkogeenien aktivoituminen.

4. Geneettisten testien hyödyt ja haitat periytyvässä syövässä (vapaaehtoinen, vastauksesta saa kaksi lisäpistettä, oma mielipide, ~1/2 sivun vastaus)

Kirjallisuuskysymys: RB ja syöpä

6.4.2005

1. määrittele lyhyesti / explain shortly

  • tuumori / tumor
  • syöpä / cancer
  • onkogeeni / oncogene
  • tuumorisupressorigeeni /tumor suppressor gene
  • “gatekeeper” / “gatekeeper”
  • “caretaker” / “caretaker”
  • nin, min, cin

2. kromosomaalisten translokaatioiden aiheuttamat geenimuutokset leukemioissa ja lymfoomissa. esimerkkeina myc-ja abl - proto-onkogeenien aktivoituminen

2. gene alterations by chromosomal translocations in leukemias and lymphomas the activation of myc- and abl-proto-oncogenes as examples

3. solusyklin säätelyssä toimivien cdk-proteiinikinaasien erilaiset säätelyt 3. the regulations of cyclin-dependent kinases in cell cycle control

4. geneettisten testien haitat ja hyödyt periytyvässä syövässä (oma mielipide).

kirjallisuuskysymys / literature periytyvä paksusuolisyöpä/ familial colorectal cancer